A High-Coverage Genome Sequence from an Archaic Denisovan Individual

Meyer, Matthias; Kircher, Martin; Gansauge, Marie-Theres; Li, Heng; Racimo, Fernando; Mallick, Swapan; G. Schraiber, Joshua; Jay, Flora; Prüfer, Kay; de Filippo, Cesare; H. Sudmant, Peter; Alkan, Can; Fu, Qiaomei; Do, Ron; Rohland, Nadin; Tandon, Arti; Siebauer, Michael; E. Green, Richard; Bryc, Katarzyna; W. Briggs, Adrian; Stenzel, Udo; Dabney, Jesse; Shendure, Jay; O. Kitzman, Jacob; F. Hammer, Michael; Shunkov, M.V.; П. Деревянко, А.; Patterson, Nick; M. Andrés, Aida; E. Eichler, Evan; Slatkin, Montgomery; Reich, David; Kelso, Janet; Pääbo, Svante

doi:10.1126/science.1224344

Public

A High-Coverage Genome Sequence from an Archaic Denisovan Individual

Published in Science • Sep 1, 2012

Authors:

Matthias Meyer

Martin Kircher

Marie-Theres Gansauge

Abstract

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archai...

Subject

Biology

Evolutionary biology

Genome

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