Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Favaudon, Vincent; Caplier, Laura; Monceau, Virginie; Pouzoulet, Frédéric; Sayarath, Mano; Fouillade, Charles; Poupon, Marie‐France; Martínez Brito, Isabel; Hupé, Philippe; Bourhis, Jean; Hall, Janet; Fontaine, Jean‐Jacques; Vozenin, Marie‐Catherine

doi:10.1126/scitranslmed.3008973

Public

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Published in Science Translational Medicine • Jul 16, 2014

Authors:

Vincent Favaudon

Laura Caplier

Virginie Monceau

Abstract

In vitro studies suggested that sub-millisecond pulses of radiation elicit less genomic instability than continuous, protracted irradiation at the same total dose. To determine the potential of ultrahigh dose-rate irradiation in radiotherapy, we investigated lung fibrogenesis in C57BL/6J mice expose...

Subject

Radiation therapy

Irradiation

Medicine

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