Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

Kikuchi, Goro; Motokawa, Yutaro; Yoshida, Tadashi; Hiraga, Koichi

doi:10.2183/pjab.84.246

Public

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

Published in Proceedings of the Japan Academy Series B • Jan 1, 2008

Authors:

Goro Kikuchi

Yutaro Motokawa

Tadashi Yoshida

Abstract

The glycine cleavage system catalyzes the following reversible reaction: Glycine + H(4)folate + NAD(+) 5,10-methylene-H(4)folate + CO(2) + NH(3) + NADH + H(+)The glycine cleavage system is widely distributed in animals, plants and bacteria and consists of three intrinsic and one common components: t...

Subject

Glycine cleavage system

Hyperglycinemia

Stereochemistry

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