SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Koch, Christine; H. Anderson, Deborah; F. Moran, Michael; Ellis, Christine; Pawson, Tony

doi:10.1126/science.1708916

Public

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Published in Science • May 3, 1991

Authors:

Christine Koch

Deborah H. Anderson

Michael F. Moran

Abstract

Src homology (SH) regions 2 and 3 are noncatalytic domains that are conserved among a series of cytoplasmic signaling proteins regulated by receptor protein-tyrosine kinases, including phospholipase C-gamma, Ras GTPase (guanosine triphosphatase)-activating protein, and Src-like tyrosine kinases. The...

Subject

SH3 domain

SH2 domain

Proto-oncogene tyrosine-protein kinase Src

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