Twelve-Month Evaluation of the Clinical Pharmacokinetics of Total and Free Mycophenolic Acid and Its Glucuronide Metabolites in Renal Allograft Recipients on Low Dose Tacrolimus in Combination with Mycophenolate Mofetil

Kuypers, Dirk; Vanrenterghem, Yves; Squifflet, Jean; Mourad, M; Abramowicz, Daniel; Oellerich, Michael; W. Armstrong, Victor; Shipkova, Maria; Daems, J

doi:10.1097/00007691-200310000-00011

Public

Twelve-Month Evaluation of the Clinical Pharmacokinetics of Total and Free Mycophenolic Acid and Its Glucuronide Metabolites in Renal Allograft Recipients on Low Dose Tacrolimus in Combination with Mycophenolate Mofetil

Published in Therapeutic Drug Monitoring • Sep 26, 2003

Authors:

Dirk Kuypers

Yves Vanrenterghem

Jean Squifflet

Abstract

BACKGROUND: The establishment of a rationale for therapeutic drug monitoring for mycophenolic acid (MPA) and outlining a therapeutic window remains a challenging task in renal transplantation. Furthermore, the pharmacokinetic characteristics of free and total MPA and its glucuronides depend directly...

Subject

Mycophenolic acid

Pharmacokinetics

Tacrolimus

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