Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

Kameyama, Yoshio; Yamashita, Keiko; Kobayashi, Kaoru; Hosokawa, Masakiyo; Chiba, Kan

doi:10.1097/01.fpc.0000170913.73780.5f

Public

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B15, SLCO1B115 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

Published in Pharmacogenetics and Genomics • Jul 1, 2005

Authors:

Yoshio Kameyama

Keiko Yamashita

Kaoru Kobayashi

Abstract

OBJECTIVES: SLCO1B1*5 and SLCO1B1*15 have been reported to reduce the clearance of pravastatin in healthy volunteers. However, there remains controversy in the effects of SLCO1B1*5 on the activity of OATP1B1 in vitro. In addition, the effect of SLCO1B1*15 on the function of OATP1B1 has not been stud...

Subject

SLCO1B1

Organic anion transporter 1

Chemistry

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