Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma

Freier, Kolja; Knoepfle, Karl; Flechtenmacher, Christa; Pungs, Susanne; Devens, Frauke; Toedt, Grischa; Hofele, Christof; Joos, Stefan; Lichter, Peter; Radlwimmer, Bernhard

doi:10.1002/gcc.20714

Public

Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma

Published in Genes Chromosomes and Cancer • Sep 29, 2009

Authors:

Kolja Freier

Karl Knoepfle

Christa Flechtenmacher

Abstract

Gene copy number aberrations are involved in oral squamous cell carcinoma (OSCC) development. To delineate candidate genes inside critical chromosomal regions, array-CGH was applied to 40 OSCC specimens using a microarray covering the whole human genome with an average resolution of 1 Mb. Gene copy ...

Subject

Copy-number variation

Biology

Gene

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