Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor

L. Basser, Russell; O’Flaherty, Elizabeth; Green, Michael; Edmonds, Maria; L. Nichol, Janet; M. Menchaca, Dora; M. Cohen, Brian; Glenn Begley, C.

doi:10.1182/blood.v99.7.2599

Public

Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor

Published in Blood • Apr 1, 2002

Authors:

Russell L. Basser

Elizabeth O’Flaherty

Michael Green

Abstract

Clinical trials of thrombopoietin (TPO), the central regulator of megakaryocytopoiesis, have revealed few side effects associated with its use. We here report a case of pancytopenia associated with the development of neutralizing antibodies to TPO that occurred in a patient who had undergone multicy...

Subject

Thrombopoietin

Pancytopenia

Megakaryocyte

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