Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I

El-Mir, Mohamad-Yehia; Nogueira, Véronique; Fontaine, Éric; Avéret, Nicole; Rigoulet, Michel; Leverve, Xavier

doi:10.1074/jbc.275.1.223

Public

Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I

Published in Journal of Biological Chemistry • Jan 1, 2000

Authors:

Mohamad-Yehia El-Mir

Véronique Nogueira

Éric Fontaine

Abstract

We report here a new mitochondrial regulation occurring only in intact cells. We have investigated the effects of dimethylbiguanide on isolated rat hepatocytes, permeabilized hepatocytes, and isolated liver mitochondria. Addition of dimethylbiguanide decreased oxygen consumption and mitochondrial me...

Subject

Respiration

Respiratory system

Cell

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