Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study

C. Gouw, Samantha; Marijke van den Berg, H.; Fischer, Kathelijn; Auerswald, Günter; Carcao, Manuel; Chalmers, Elizabeth; Chambost, Hervé; Kurnik, Karin; Liesner, Ri; Petrini, Pia; Platokouki, Helen; Altisent, Carmen; Oldenburg, Johannes; Nolan, Beatrice; Pérez Garrido, Rosario; Elisa Mancuso, M.; Rafowicz, Anne; Williams, Mike; Clausen, Niels; A. Middelburg, Rutger; Ljung, Rolf; G. van der Bom, Johanna

doi:10.1182/blood-2012-09-457036

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Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study

Shared by NobleBlocks on May 16, 2013 • 12:00 AM UTC

Authors:

Samantha C. Gouw

H. Marijke van den Berg

Kathelijn Fischer

Abstract

Key Points High-dose intensive factor VIII treatment increases the risk for inhibitor development in patients with severe hemophilia A. In patients with severe hemophilia A, factor VIII prophylaxis decreases inhibitor risk, especially in patients with low-risk F8 mutations.

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