Circadian Modulation of Dopamine Levels and Dopaminergic Neuron Development Contributes to Attention Deficiency and Hyperactive Behavior

Huang, Jian; Zhong, Zhaomin; Wang, Mingyong; Chen, Xifeng; Tan, Yicheng; Zhang, Shuqing; He, Wei; He, Xiong; Huang, Guodong; Lu, Haiping; Wu, Ping; Che, Yi; Yan, Yi‐Lin; H. Postlethwait, John; Chen, Wenbiao; Wang, Han

doi:10.1523/jneurosci.2551-14.2015

Public

Circadian Modulation of Dopamine Levels and Dopaminergic Neuron Development Contributes to Attention Deficiency and Hyperactive Behavior

Published in Journal of Neuroscience • Feb 11, 2015

Authors:

Jian Huang

Zhaomin Zhong

Mingyong Wang

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adults. While ADHD patients often display circadian abnormalities, the underlying mechanisms are unclear. Here we found that the zebrafish mutant for the circadian gene period1b (per1b)...

Subject

Circadian rhythm

Dopamine

Dopaminergic

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