Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior.

J, Huang; Z, Zhong; M, Wang; X, Chen; Y, Tan; S, Zhang; W, He; X, He; G, Huang; H, Lu; P, Wu; Y, Che; YL, Yan; JH, Postlethwait; W, Chen; H, Wang

doi:10.1523/jneurosci.2551-14.2015

Public

Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior.

Shared by NobleBlocks on Feb 1, 2015 • 12:00 AM UTC

Authors:

Huang J

Zhong Z

Wang M

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adults. While ADHD patients often display circadian abnormalities, the underlying mechanisms are unclear. Here we found that the zebrafish mutant for the circadian gene period1b (per1b)...

Subject

Dopamine

Zebrafish

Circadian clock

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