Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism

Casini, Alessandro; Cunningham, Mike; Rojkind, Marcos; S. Lieber, Charles

doi:10.1002/hep.1840130424

Public

Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism

Published in Hepatology • Apr 1, 1991

Authors:

Alessandro Casini

Mike Cunningham

Marcos Rojkind

Abstract

We previously reported that acetaldehyde increases the production of type I collagen in cultured rat fat-storing cells. We studied the regulation of this effect by determining the expression of procollagen type I, fibronectin and transforming growth factor-beta 1 messenger RNAs in passage 1 and 2 cu...

Subject

Procollagen peptidase

Acetaldehyde

Fibronectin

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