<b><i>PTEN</i></b> deletion and heme oxygenase‐1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome

Li, Yunru; Su, Jie; DingZhang, Xiao; Zhang, Jianguo; Yoshimoto, Maisa; Liu, Shuhong; Bijian, Krikor; Gupta, Ajay; A. Squire, Jeremy; A Alaoui Jamali, Moulay; A. Bismar, Tarek

doi:10.1002/path.2855

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PTEN deletion and heme oxygenase‐1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome

Published in The Journal of Pathology • Jan 10, 2011

Authors:

Yunru Li

Jie Su

Xiao DingZhang

Abstract

Overexpression of the pro-survival protein heme oxygenase-1 (HO-1) and loss of the pro-apoptotic tumour suppressor PTEN are common events in prostate cancer (PCA). We assessed the occurrence of both HO-1 expression and PTEN deletion in two cohorts of men with localized and castration-resistant prost...

Subject

PTEN

Prostate cancer

Cancer research

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