Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

Ziegler, Elizabeth; J. Fisher, Charles; L. Sprung, Charles; Straube, Richard; Sadoff, Jerald; E. Foulke, Garrett; H. Wortel, Cornelis; P. Fink, Mitchell; Phillip Dellinger, R.; N.H. Teng, Nelson; Elaine Allen, I.; J. Berger, Harvey; L. Knatterud, Genell; F. LoBuglio, Albert; R. Smith, Craig; HA-1A Sepsis Study Group, the

doi:10.1056/nejm199102143240701

Public

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

Published in New England Journal of Medicine • Feb 14, 1991

Authors:

Elizabeth Ziegler

Charles J. Fisher

Charles L. Sprung

Abstract

BACKGROUND: HA-1A is a human monoclonal IgM antibody that binds specifically to the lipid A domain of endotoxin and prevents death in laboratory animals with gram-negative bacteremia and endotoxemia. METHODS: To evaluate the efficacy and safety of HA-1A, we conducted a randomized, double-blind trial...

Subject

Bacteremia

Medicine

Sepsis

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