The role of hypoxia-inducible factor-2 in digestive system cancers

Abstract Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible factors (HIFs), HIF-1 α and HIF-2 α , primarily mediate the transcriptional response to hypoxia. Despite the high homology between HIF-1 α and HIF-2 α , emerging evidence suggests differences between both mo... View More