Autophagy Inhibition Contributes to the Synergistic Interaction between EGCG and Doxorubicin to Kill the Hepatoma Hep3B Cells

Chen, Li; Ye, Huilan; Zhang, Guo; Yao, Wenmin; Chen, Xing‐Zhou; Zhang, Fa‐Can; Liang, Gang

doi:10.1371/journal.pone.0085771

Public

Autophagy Inhibition Contributes to the Synergistic Interaction between EGCG and Doxorubicin to Kill the Hepatoma Hep3B Cells

Published in PLoS ONE • Jan 21, 2014

Authors:

Li Chen

Huilan Ye

Guo Zhang

Abstract

(-)-Epigallocatechin-3-O-gallate(EGCG), the highest catechins from green tea, has promisingly been found to sensitize the efficacy of several chemotherapy agents like doxorubicin (DOX) in hepatocellular carcinoma (HCC) treatment. However, the detailed mechanisms by which EGCG augments the chemothera...

Subject

Autophagy

ATG5

Chemosensitizer

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