HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O
                    <sub>2</sub>
                    Sensing

Ivan, Mircea; Kondo, Keiichi; Yang, Haifeng; Kim, William; Valiando, Jennifer; Ohh, Michael; Salic, Adrian; M. Asara, John; S. Lane, William; G. Kaelin Jr., William

doi:10.1126/science.1059817

Public

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Shared by NobleBlocks on Apr 20, 2001 • 12:00 AM UTC

Authors:

Mircea Ivan

Keiichi Kondo

Haifeng Yang

Abstract

HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippel–Lindau tumor suppressor protein (pVHL). We found...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!