HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Ivan, Mircea; Kondo, Keiichi; Yang, Haifeng; Kim, William; Valiando, Jennifer; Ohh, Michael; Salic, Adrian; M. Asara, John; S. Lane, William; G. Kaelin, William

doi:10.1126/science.1059817

Public

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Published in Science • Apr 20, 2001

Authors:

Mircea Ivan

Keiichi Kondo

Haifeng Yang

Abstract

HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippel-Lindau tumor suppressor protein (pVHL). We found...

Subject

Hydroxylation

Ubiquitin ligase

Proline

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