Striatal progenitors derived from human ES cells mature into DARPP32 neurons <i>in vitro</i> and in quinolinic acid-lesioned rats

Aubry, Laëtitia; Bugi, Aurore; Lefort, Nathalie; Rousseau, France; Peschanski, Marc; L. Perrier, Anselme

doi:10.1073/pnas.0808488105

Public

Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats

Published in Proceedings of the National Academy of Sciences • Oct 15, 2008

Authors:

Laëtitia Aubry

Aurore Bugi

Nathalie Lefort

Abstract

Substitutive cell therapy using fetal striatal grafts has demonstrated preliminary clinical success in patients with Huntington's disease, but the logistics required for accessing fetal cells preclude its extension to the relevant population of patients. Human embryonic stem (hES) cells theoreticall...

Subject

Progenitor cell

Embryonic stem cell

Quinolinic acid

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