Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

Varambally, Sooryanarayana; Cao, Qi; S. Mani, Ram; Shankar, Sunita; Wang, Xiaosong; Ateeq, Bushra; Laxman, Bharathi; Cao, Xuhong; Jing, Xiaojun; Ramnarayanan, Kalpana; Chad Brenner, J.; Yu, Jindan; H. Kim, Jung; Han, Bo; Tan, Patrick; Kumar‐Sinha, Chandan; J. Lonigro, Robert; Palanisamy, Nallasivam; A. Maher, Christopher; M. Chinnaiyan, Arul

doi:10.1126/science.1165395

Public

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

Published in Science • Nov 13, 2008

Authors:

Sooryanarayana Varambally

Qi Cao

Ram S. Mani

Abstract

Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain unclear. Here we show that th...

Subject

EZH2

Histone methyltransferase

microRNA

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