von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease

Sanders, Yvonne; J. Groeneveld, Dafna; Meijer, Karina; Fijnvandraat, Karin; H. Cnossen, Marjon; G. van der Bom, Johanna; Coppens, Michiel; de Meris, Joke; A. P. Laros‐van Gorkom, Britta; P. Mauser‐Bunschoten, Eveline; W.G. Leebeek, Frank; Eikenboom, Jeroen; WiN study group, the

doi:10.1182/blood-2014-09-603241

Public

von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease

Published in Blood • Feb 12, 2015

Authors:

Yvonne Sanders

Dafna J. Groeneveld

Karina Meijer

Abstract

The ratios between von Willebrand factor propeptide (VWFpp) or factor VIII activity ( FVIII: C) and VWF antigen (VWF:Ag) reflect synthesis, secretion, and clearance of VWF. We aimed to define the pathophysiology of 658 patients with type 1, 2, or 3 von Willebrand disease (VWD) with VWF levels ≤30 U/...

Subject

Von Willebrand factor

Von Willebrand disease

Protein precursor

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