ERK1 plays a critical protective role against <i>N</i>‐methyl‐<scp>D</scp>‐aspartate‐induced retinal injury

Nakazawa, Toru; Shimura, Masahiko; Ryu, Morin; Nishida, Kohji; Pagès, Gilles; Pouysségur, Jacques; Endo, Shogo

doi:10.1002/jnr.21472

Public

ERK1 plays a critical protective role against N‐methyl‐D‐aspartate‐induced retinal injury

Published in Journal of Neuroscience Research • Aug 24, 2007

Authors:

Toru Nakazawa

Masahiko Shimura

Morin Ryu

Abstract

Excitotoxicity has been implicated in several ischemic diseases of the retina, including retinal vessel occlusion and diabetic retinopathy. Glutamate signaling mediated through the N-methyl-D-aspartate (NMDA) receptor contributes to ischemic cell death. The NMDA receptor antagonists MK-801 and meman...

Subject

Retinal

Pharmacology

Neuroscience

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