Direct Detection of Alternative Open Reading Frames Translation Products in Human Significantly Expands the Proteome

Vanderperre, Benoît; Lucier, Jean‐François; Bissonnette, Cyntia; Motard, Julie; Tremblay, Guillaume; Vanderperre, Solène; Wisztorski, Maxence; Salzet, Michel; Boisvert, François‐Michel; Roucou, Xavier

doi:10.1371/journal.pone.0070698

Public

Direct Detection of Alternative Open Reading Frames Translation Products in Human Significantly Expands the Proteome

Published in PLoS ONE • Aug 12, 2013

Authors:

Benoît Vanderperre

Jean‐François Lucier

Cyntia Bissonnette

Abstract

A fully mature mRNA is usually associated to a reference open reading frame encoding a single protein. Yet, mature mRNAs contain unconventional alternative open reading frames (AltORFs) located in untranslated regions (UTRs) or overlapping the reference ORFs (RefORFs) in non-canonical +2 and +3 read...

Subject

Proteome

Open reading frame

Human proteome project

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!