Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.

G, Illuzzi; C, Bernacchioni; M, Aureli; S, Prioni; G, Frera; C, Donati; M, Valsecchi; V, Chigorno; P, Bruni; S, Sonnino; A, Prinetti

doi:10.1074/jbc.m109.072801

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Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.

Shared by NobleBlocks on Apr 19, 2010 • 12:00 AM UTC

Authors:

Illuzzi G

Bernacchioni C

Aureli M

Abstract

A2780 human ovarian carcinoma cells respond to treatment with the synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR) with the production of dihydroceramide and with a concomitant reduction of cell proliferation and induction of apoptosis. The derived HPR-resistant clonal cell line, A2780/HPR, is...

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