Connecting TNF-α Signaling Pathways to iNOS Expression in a Mouse Model of Alzheimer's Disease: Relevance for the Behavioral and Synaptic Deficits Induced by Amyloid β Protein

Medeiros, Rodrigo; Daniel Prediger, Rui; F. Passos, Giselle; Pandolfo, Pablo; Silveira Duarte, Filipe; Luís Franco, Jeferson; Luiz Dafré, Alcir; Di Giunta, Gabriella; P. Figueiredo, Cláudia; Ν. Takahashi, Reinaldo; M. Campos, Maria; Β. Calixto, João

doi:10.1523/jneurosci.5047-06.2007

Public

Connecting TNF-α Signaling Pathways to iNOS Expression in a Mouse Model of Alzheimer's Disease: Relevance for the Behavioral and Synaptic Deficits Induced by Amyloid β Protein

Published in Journal of Neuroscience • May 16, 2007

Authors:

Rodrigo Medeiros

Rui Daniel Prediger

Giselle F. Passos

Abstract

Increased brain deposition of amyloid beta protein (Abeta) and cognitive deficits are classical signals of Alzheimer's disease (AD) that have been highly associated with inflammatory alterations. The present work was designed to determine the correlation between tumor necrosis factor-alpha (TNF-alph...

Subject

Neuroscience

Disease

Signal transduction

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