<i>In Vivo</i> Retrovirus-Mediated Gene Transfer to the Liver of Dogs Results in Transient Expression and Induction of a Cytotoxic Immune Response

Izembart, Anne; Aguado, Eric; Gauthier, Olivier; Aubert, Dominique; Moullier, Philippe; Ferry, Nicolas

doi:10.1089/10430349950016339

Public

In Vivo Retrovirus-Mediated Gene Transfer to the Liver of Dogs Results in Transient Expression and Induction of a Cytotoxic Immune Response

Published in Human Gene Therapy • Dec 10, 1999

Authors:

Anne Izembart

Eric Aguado

Olivier Gauthier

Abstract

Gene transfer in regenerating dog liver using high-titer recombinant retroviral vectors carrying the E. coli beta-galactosidase gene was studied. Supernatants containing amphotropic or gibbon ape pseudotyped recombinant retroviruses were infused into a peripheral vein in beagle dogs after partial he...

Subject

Cytotoxic T cell

Biology

Immune system

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