Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Dreux, Nicolas; Denizot, Jérémy; Martínez-Medina, Margarita; Mellmann, Alexander; Billig, Maria; Kisiela, Dagmara; Chattopadhyay, Sujay; V. Sokurenko, Evgeni; Neut, Christel; Gower‐Rousseau, Corinne; Colombel, Jean‐Frédéric; Bonnet, Richard; Darfeuille–Michaud, Arlette; Barnich, Nicolas

doi:10.1371/journal.ppat.1003141

Public

Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Published in PLoS Pathogens • Jan 24, 2013

Authors:

Nicolas Dreux

Jérémy Denizot

Margarita Martínez-Medina

Abstract

Adherent-invasive Escherichia coli (AIEC) are abnormally predominant on Crohn's disease (CD) ileal mucosa. AIEC reference strain LF82 adheres to ileal enterocytes via the common type 1 pili adhesin FimH and recognizes CEACAM6 receptors abnormally expressed on CD ileal epithelial cells. The fimH gene...

Subject

Biology

Bacterial adhesin

Microbiology

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