Tissue Specific Regulation of Glucocorticoids in Severe Obesity and the Response to Significant Weight Loss Following Bariatric Surgery (BARICORT)

Woods, Conor; Corrigan, M.; Gathercole, Laura; E. Taylor, Angela; Hughes, Beverly; Gaoatswe, Gadintshware; Manolopoulos, Konstantinos; E. Hogan, Andrew; O’Connell, Jean; M. Stewart, Paul; Tomlinson, Jeremy; O’Shea, Donal; Sherlock, Mark

doi:10.1210/jc.2014-4120

Public

Tissue Specific Regulation of Glucocorticoids in Severe Obesity and the Response to Significant Weight Loss Following Bariatric Surgery (BARICORT)

Published in The Journal of Clinical Endocrinology & Metabolism • Jan 20, 2015

Authors:

Conor Woods

M. Corrigan

Laura Gathercole

Abstract

CONTEXT: Tissue cortisol exposure is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-HSD1 in vivo, acts as an oxoreductase converting inactive cortisone to active cortisol. We hypothesized that 11β-HSD1 activity is dysregulated in obesity and alters following bar...

Subject

Adipose tissue

Cortisone

Weight loss

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