Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)

Lee, Seung-Jin; Jang, Byeong-Churl; Lee, Soo-Woong; Yang, Young-Il; Suh, Seong-Il; Park, Yeong-Min; Oh, Sangtaek; Shin, Jae-Gook; Yao, Sheng; Chen, Lieping; Choi, In-Hak

doi:10.1016/j.febslet.2005.12.093

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Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)

Shared by NobleBlocks on Jan 9, 2006 • 12:00 AM UTC

Authors:

Seung-Jin Lee

Byeong-Churl Jang

Soo-Woong Lee

Abstract

Majority of cancer cells upregulate co‐inhibitory molecule B7‐H1 which confers resistance to anti‐tumor immunity, allowing cancers to escape from host immune surveillance. We addressed the molecular mechanism underlying the regulation of cancer‐associated B7‐H1 expression in response to interferon‐γ...

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