Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

Beuschlein, Felix; Faßnacht, Martin; Assié, Guillaume; Calebiro, Davide; A. Stratakis, Constantine; Oßwald, Andrea; L. Ronchi, Cristina; Wieland, Thomas; Sbiera, Silviu; R. Faucz, Fábio; Schaak, Katrin; Schmittfull, Anett; Schwarzmayr, Thomas; Barreau, Olivia; Vezzosi, Delphine; Rizk‐Rabin, Marthe; Zabel, Ulrike; Szarek, Eva; Salpea, Paraskevi; Forlino, Antonella; Vetro, Annalisa; Zuffardi, Orsetta; Kisker, Caroline; Diener, Susanne; Meitinger, Thomas; J. Lohse, Martin; Reincke, Martín; Bertherat, Jérôme; M. Strom, Tim; Allolio, Bruno

doi:10.1056/nejmoa1310359

Public

Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

Published in New England Journal of Medicine • Feb 26, 2014

Authors:

Felix Beuschlein

Martin Faßnacht

Guillaume Assié

Abstract

BACKGROUND: Corticotropin-independent Cushing's syndrome is caused by tumors or hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal adenomas is not well understood. METHODS: We performed exome sequencing of tumor-tissue specimens from 10 patients with cortisol...

Subject

Adrenal cortex

Endocrinology

Pathogenesis

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