An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Williams Parsons, D.; Jones, Siân; Zhang, Xiaosong; Lin, Jimmy; Leary, Rebecca; Angenendt, Philipp; K. Mankoo, Parminder; Carter, Hannah; Siu, I‐Mei; L. Gallia, Gary; Olivi, Alessandro; E. McLendon, Roger; Ahmed Rasheed, B.; T. Keir, Stephen; Nikolskaya, Tatiana; Nikolsky, Yuri; Busam, Dana; Tekleab, Hanna; A. Díaz, Luis; Hartigan, James; Smith, Doug; L. Strausberg, Robert; Kazue Nagahashi Marie, Suely; Mieko Oba‐Shinjo, Sueli; Yan, Hai; J. Riggins, Gregory; D. Bigner, Darell; Karchin, Rachel; Papadopoulos, Nick; Parmigiani, Giovanni; Vogelstein, Bert; E. Velculescu, Victor; W. Kinzler, Kenneth

doi:10.1126/science.1164382

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An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Published in Science • Sep 4, 2008

Authors:

D. Williams Parsons

Siân Jones

Xiaosong Zhang

Abstract

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and deletions using high-density oligonucleotide arrays, and performed gene expression an...

Subject

IDH1

Isocitrate dehydrogenase

Glioblastoma

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