Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling

V. Shih, Yu‐Ru; Hwang, Yongsung; Phadke, Ameya; Kang, Heemin; S. Hwang, Nathaniel; J. E. Caro‐Diaz, Eduardo; Nguyen, Steven; Siu, Michael; A. Theodorakis, Emmanuel; C. Gianneschi, Nathan; S. Vecchio, Kenneth; Chien, Shu; K. Lee, Oscar; Varghese, Shyni

doi:10.1073/pnas.1321717111

Public

Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling

Published in Proceedings of the National Academy of Sciences • Jan 6, 2014

Authors:

Yu‐Ru V. Shih

Yongsung Hwang

Ameya Phadke

Abstract

Synthetic matrices emulating the physicochemical properties of tissue-specific ECMs are being developed at a rapid pace to regulate stem cell fate. Biomaterials containing calcium phosphate (CaP) moieties have been shown to support osteogenic differentiation of stem and progenitor cells and bone tis...

Subject

Cell biology

Stem cell

Paracrine signalling

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