The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL)

Palladini, Giovanni; Perfetti, Vittorio; Perlini, Stefano; Obici, Laura; Lavatelli, Francesca; Caccialanza, Riccardo; Invernizzi, Rosangela; Comotti, Benedetto; Merlini, Giampaolo

doi:10.1182/blood-2004-08-3231

Public

The combination of thalidomide and intermediate-dose dexamethasone is an effective but toxic treatment for patients with primary amyloidosis (AL)

Published in Blood • Dec 1, 2004

Authors:

Giovanni Palladini

Vittorio Perfetti

Stefano Perlini

Abstract

Based on the efficacy of thalidomide in multiple myeloma and on its synergy with dexamethasone on myeloma plasma cells, we evaluated the combination of thalidomide (100 mg/d, with 100-mg increments every 2 weeks, up to 400 mg) and dexamethasone (20 mg on days 1-4) every 21 days in 31 patients with p...

Subject

Thalidomide

Dexamethasone

Medicine

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