Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

V. Castell, José; José Gómez-Lechón, Marı́a; David, Martina; Andus, Tilo; Geiger, Thomas; Trullenque, Ramón; Fabra, Ricardo; C. Heinrich, Peter

doi:10.1016/0014-5793(89)80476-4

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Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

Published in FEBS Letters • Jan 2, 1989

Authors:

José V. Castell

Marı́a José Gómez-Lechón

Martina David

Abstract

The three monokines interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), and interleukin-6 (IL-6) modulate acute phase plasma protein synthesis in adult human hepatocytes. Only IL-6 stimulates the synthesis of the full spectrum of acute phase proteins as seen in inflammatory stat...

Subject

Acute-phase protein

Haptoglobin

Transferrin

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