Distinct patterns of brain activity in young carriers of the <i>APOE</i> -ε4 allele

Filippini, Nicola; J. MacIntosh, Bradley; Hough, M.; M. Goodwin, Guy; B. Frisoni, Giovanni; M. Smith, Stephen; M. Matthews, Paul; F. Beckmann, Christian; E. Mackay, Clare

doi:10.1073/pnas.0811879106

Public

Distinct patterns of brain activity in young carriers of the APOE -ε4 allele

Published in Proceedings of the National Academy of Sciences • Apr 8, 2009

Authors:

Nicola Filippini

Bradley J. MacIntosh

M. Hough

Abstract

The APOE epsilon4 allele is a risk factor for late-life pathological changes that is also associated with anatomical and functional brain changes in middle-aged and elderly healthy subjects. We investigated structural and functional effects of the APOE polymorphism in 18 young healthy APOE epsilon4-...

Subject

Apolipoprotein E

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Allele

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