Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin

De Togni, Pietro; J. Goellner, Joseph; H. Ruddle, Nancy; R. Streeter, Philip; Andrea, Fick; Mariathasan, Sanjeev; C. Smith, Stacy; Carlson, Rebecca; P. Shornick, Laurie; Strauss‐Schoenberger, Jena; H. Russell, John; W. Karr, Robert; Chaplin, David

doi:10.1126/science.8171322

Public

Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin

Published in Science • Apr 29, 1994

Authors:

Pietro De Togni

Joseph J. Goellner

Nancy H. Ruddle

Abstract

Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Sp...

Subject

Lymphotoxin

White pulp

Spleen

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