Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

Z. Imtiyaz, Hongxia; Williams, Emily; M. Hickey, Michele; Patel, Shetal; C. Durham, Amy; Yuan, Lijun; Hammond, Rachel; A. Gimotty, Phyllis; Keith, Brian; Celeste Simon, M.

doi:10.1172/jci39506

Public

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

Published in Journal of Clinical Investigation • Jul 19, 2010

Authors:

Hongxia Z. Imtiyaz

Emily Williams

Michele M. Hickey

Abstract

Hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha display unique and sometimes opposing activities in regulating cellular energy homeostasis, cell fate decisions, and oncogenesis. Macrophages exposed to hypoxia accumulate both HIF-1alpha and HIF-2alpha, and overexpression of HIF-2alpha in ...

Subject

Chemokine

Inflammation

Proinflammatory cytokine

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