Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis

M. van Laar, Jacob; Farge, Dominique; K. Sont, Jacob; Naraghi, Kamran; Marjanovic, Zora; Larghero, Jérôme; J. Schuerwegh, Annemie; W.A. Marijt, Erik; C. Vonk, Madelon; Schattenberg, A; Matucci‐Cerinic, Marco; E. Voskuyl, Alexandre; A. van de Loosdrecht, Arjan; Daikeler, Thomas; Kötter, Ina; Schmalzing, Marc; Martin, Thierry; Lioure, Bruno; M. Weiner, Stefan; Kreuter, Alexander; Deligny, C.; Durand, J.M.; Emery, Paul; Machold, Klaus; Sarrot-Reynauld, F.; Warnatz, Klaus; Adoué, D.; Constans, J.; Tony, Hans‐Peter; Del Papa, Nicoletta; Fassas, Αthanasios; Himsel, Andrea; Launay, David; Lo Monaco, Andrea; Philippe, Pierre; Quéré, I.; Rich, Éric; Westhovens, René; Griffiths, Bridget; Saccardi, Riccardo; van den Hoogen, F.H.J.; E. Fibbe, Willem; Socié, Gèrard; Gratwohl, Aloïs; Tyndall, A

doi:10.1001/jama.2014.6368

Public

Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis

Published in JAMA • Jun 24, 2014

Authors:

Jacob M. van Laar

Dominique Farge

Jacob K. Sont

Abstract

IMPORTANCE: High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small phase 2 trials. OBJECTIVE: To compare efficacy and safety of HSCT vs 12 successive monthly intravenous pulses of cyclophosphami...

Subject

Medicine

Cyclophosphamide

Hematopoietic stem cell transplantation

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