Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Hasegawa, Masato; Arai, Tetsuaki; Nonaka, Takashi; Kametani, Fuyuki; Yoshida, Mari; Hashizume, Yoshio; G. Beach, Thomas; Buratti, Emanuele; E. Baralle, Francisco; Morita, Mitsuya; Nakano, Imaharu; Oda, Tatsuro; Tsuchiya, Kuniaki; Akiyama, Haruhiko

doi:10.1002/ana.21425

Public

Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Published in Annals of Neurology • Jun 10, 2008

Authors:

Masato Hasegawa

Tetsuaki Arai

Takashi Nonaka

Abstract

OBJECTIVE: TAR DNA-binding protein of 43kDa (TDP-43) is deposited as cytoplasmic and intranuclear inclusions in brains of patients with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). Previous studies reported that abnormal phosphoryl...

Subject

Phosphorylation

Frontotemporal lobar degeneration

Amyotrophic lateral sclerosis

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