Effect of molecular weight (Mw) ofN‐(2‐hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats

W. Seymour, Leonard; Duncan, Ruth; Strohalm, J.; Kopeček, Jindřich

doi:10.1002/jbm.820211106

Public

Effect of molecular weight (Mw) ofN‐(2‐hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats

Published in Journal of Biomedical Materials Research • Nov 1, 1987

Authors:

Leonard W. Seymour

Ruth Duncan

J. Strohalm

Abstract

A copolymer of N-(2-hydroxypropyl) methacrylamide (HPMA) and N-methacryloyltyrosinamide was prepared and fractionated using Sepharose 4B/6B (1:1) chromatography to produce eight HPMA copolymer fractions of narrow polydispersity and mean molecular weight (Mw) ranging from 12 to 778 kD. These fraction...

Subject

Extravasation

Methacrylamide

Distribution (mathematics)

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