Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein

Gutsche, Irina; Coulibaly, Fasséli; E. Voss, James; Salmon, Jérôme; d'Alayer, Jacques; Ermonval, Myriam; Larquet, Eric; Charneau, Pierre; Krey, Thomas; Mégret, Françoise; Guittet, Eric; A. Rey, Félix; Flamand, Marie

doi:10.1073/pnas.1017338108

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Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein

Shared by NobleBlocks on Apr 25, 2011 • 12:00 AM UTC

Authors:

Irina Gutsche

Fasséli Coulibaly

James E. Voss

Abstract

Dengue virus (DENV) causes the major arboviral disease of the tropics, characterized in its severe forms by signs of hemorrhage and plasma leakage. DENV encodes a nonstructural glycoprotein, NS1, that associates with intracellular membranes and the cell surface. NS1 is eventually secreted as a solub...

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