Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

A. Lanaspa, Miguel; Gabriela Sánchez‐Lozada, Laura; Choi, Yea-Jin; Cicerchi, Christina; Kanbay, Mehmet; A. Roncal-Jiménez, Carlos; Ishimoto, Takuji; Li, Nanxing; Marek, George; Duranay, Murat; F. Schreiner, George; Rodríguez‐Iturbe, Bernardo; Nakagawa, Takahiko; Kang, Duk‐Hee; Y. Sautin, Yuri; J. Johnson, Richard

doi:10.1074/jbc.m112.399899

Public

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

Published in Journal of Biological Chemistry • Oct 4, 2012

Authors:

Miguel A. Lanaspa

Laura Gabriela Sánchez‐Lozada

Yea-Jin Choi

Abstract

BACKGROUND: Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown. RESULTS: Hepatocytes exposed to uric acid developed mitochondrial dysfunction and increased de novo lipogenesis, and its blockade prevented fructose-induced lip...

Subject

Steatosis

Oxidative stress

Uric acid

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