Cooperative Interaction of EWS with CREB-binding Protein Selectively Activates Hepatocyte Nuclear Factor 4-mediated Transcription

Araya, Natsumi; Hirota, Keiko; Shimamoto, Yoko; Miyagishi, Makoto; Yoshida, Eisaku; Ishida, Junji; Kaneko, Setsuko; Kaneko, Michio; Nakajima, Toshihiro; Fukamizu, Akiyoshi

doi:10.1074/jbc.m210234200

Public

Cooperative Interaction of EWS with CREB-binding Protein Selectively Activates Hepatocyte Nuclear Factor 4-mediated Transcription

Published in Journal of Biological Chemistry • Feb 1, 2003

Authors:

Natsumi Araya

Keiko Hirota

Yoko Shimamoto

Abstract

The EWS gene when fused to transcription factors such as the ETS family ATF-1, Wilms' tumor-1, and nuclear orphan receptors upon chromosomal translocation is thought to contribute the development of Ewing sarcoma and several malignant tumors. Although EWS is predicted to be an RNA-binding protein, a...

Subject

CREB

Transcription factor

Chemistry

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