E31 Positron Emission Tomography Imaging Of Phosphodiesterase 10 A Enzyme And Dopamine D2 Receptor In Huntington's Disease Gene Expansion Carriers

Fazio, Patrik; Fitzer‐Attas, Cheryl; Mrzljak, Ladislav; Martinsson, Stefan; Bernhard Landwehrmeyer, G.; Bronzova, J.; Al‐Tawil, Nabil; Halldin, Christer; Sampaio, Cristina; Varrone, Andrea

doi:10.1136/jnnp-2014-309032.134

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E31 Positron Emission Tomography Imaging Of Phosphodiesterase 10 A Enzyme And Dopamine D2 Receptor In Huntington's Disease Gene Expansion Carriers

Published in Journal of Neurology Neurosurgery & Psychiatry • Sep 1, 2014

Authors:

Patrik Fazio

Cheryl Fitzer‐Attas

Ladislav Mrzljak

Abstract

Background Degeneration of striatal medium-spiny neurons is a pathological feature of Huntington´s disease (HD). D2 receptor imaging with positron emission tomography (PET) is a marker of neuronal integrity in HD. Phosphodiesterase 10A (PDE10A) enzyme is highly enriched in the striatal medium-spiny ...

Subject

Raclopride

Binding potential

Positron emission tomography

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