Aβ Oligomers Cause Localized Ca 2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

Zempel, Hans; Thies, Edda; Mandelkow�, Eckhard; Mandelkow, Eva‐Maria; Mandelkow, Eva‐Maria; Mandelkow, Eva‐Maria

doi:10.1523/jneurosci.2357-10.2010

Public

Aβ Oligomers Cause Localized Ca 2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

Published in Journal of Neuroscience • Sep 8, 2010

Authors:

Hans Zempel

Edda Thies

Eckhard Mandelkow�

Abstract

Aggregation of amyloid-beta (Abeta) and Tau protein are hallmarks of Alzheimer's disease (AD), and according to the Abeta-cascade hypothesis, Abeta is considered toxic for neurons and Tau a downstream target of Abeta. We have investigated differentiated primary hippocampal neurons for early localize...

Subject

Microtubule

Cell biology

Phosphorylation

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