EVALUATION OF A TWO-GENERATION REPRODUCTION TOXICITY STUDY ADDING ENDOPOINTS TO DETECT ENDOCRINE DISRUPTING ACTIVITY USING VINCLOZOLIN

Matsuura, Ikuo; SAITOH, Tetsuji; Ashina, Michiko; Wako, Yumi; Iwata, Hiroshi; Toyota, Naoto; ISHIZUKA, Yoshihito; Namiki, Masato; Hoshino, Nobuhito; Tsuchitani, Minoru

doi:10.2131/jts.30.s163

Public

EVALUATION OF A TWO-GENERATION REPRODUCTION TOXICITY STUDY ADDING ENDOPOINTS TO DETECT ENDOCRINE DISRUPTING ACTIVITY USING VINCLOZOLIN

Published in The Journal of Toxicological Sciences • Jan 1, 2005

Authors:

Ikuo Matsuura

Tetsuji SAITOH

Michiko Ashina

Abstract

A two-generation reproduction toxicity study in rats adding extra endpoints to detect endocrine disrupting activity was conducted using vinclozolin by dietary administration at 0, 40, 200, and 1000 ppm, for investigation of its utility. The extra endpoints included anogenital distance (AGD), nipple ...

Subject

Anogenital distance

Internal medicine

Endocrinology

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