Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans

Takahashi, Harumi; Wilkinson, G.; A. Nutescu, Edith; Morita, Takashi; D. Ritchie, Marylyn; Gabriella Scordo, Maria; Pengo, Vittorio; Barban, Martina; Padrini, Roberto; Ieiri, Ichiro; Otsubo, Kenji; Kashima, Toshitaka; Kimura, Sosuke; Kijima, Shinichi; Echizen, Hirotoshi

doi:10.1097/01.fpc.0000184955.08453.a8

Public

Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans

Published in Pharmacogenetics and Genomics • Feb 1, 2006

Authors:

Harumi Takahashi

G. Wilkinson

Edith A. Nutescu

Abstract

OBJECTIVE: To investigate pharmacokinetic and pharmacodynamic factors associated with population differences in warfarin doses needed to achieve anticoagulation, in particular the possible involvement of genetic variability in vitamin K epoxide reductase (VKOR) and CYP2C9. METHODS: Warfarin maintena...

Subject

VKORC1

Vitamin K epoxide reductase

Warfarin

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