Amplification and Overexpression of <i>CTTN</i> ( <i>EMS1</i> ) Contribute to the Metastasis of Esophageal Squamous Cell Carcinoma by Promoting Cell Migration and Anoikis Resistance

Luo, Man‐Li; Shen, Xiaoming; Zhang, Yu; Fang, Wei; Xu, Xin; Cai, Yan; Zhang, Xun; Sun, Yun-tian; Zhan, Qimin; Wu, Min; Wang, Ming‐Rong

doi:10.1158/0008-5472.can-06-1484

Public

Amplification and Overexpression of CTTN ( EMS1 ) Contribute to the Metastasis of Esophageal Squamous Cell Carcinoma by Promoting Cell Migration and Anoikis Resistance

Published in Cancer Research • Dec 15, 2006

Authors:

Man‐Li Luo

Xiaoming Shen

Yu Zhang

Abstract

Gain of chromosome 11q13 is a common event in esophageal squamous cell carcinoma (ESCC). The cortactin gene (CTTN, also EMS1), located at 11q13, plays a pivotal role in coupling membrane dynamics to cortical actin assembly. This gene has been implicated in the motility of several types of cells. In ...

Subject

Anoikis

Cancer research

Metastasis

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