Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials

Ferreira‐González, Ignacio; Permanyer-Miralda, Gaiet; Domingo‐Salvany, Antònia; W. Busse, Jason; Heels‐Ansdell, Diane; M. Montori, Víctor; A. Akl, Elie; Bryant, Dianne; Alonso‐Coello, Pablo; Alonso, Jordi; Worster, Andrew; Upadhye, Suneel; Jaeschke, Roman; J. Schünemann, Holger; Pacheco‐Huergo, Valeria; Wu, Ping; J. Mills, Edward; Guyatt, Gordon

doi:10.1136/bmj.39136.682083.ae

Public

Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials

Published in BMJ • Apr 2, 2007

Authors:

Ignacio Ferreira‐González

Gaiet Permanyer-Miralda

Antònia Domingo‐Salvany

Abstract

OBJECTIVE: To explore the extent to which components of composite end points in randomised controlled trials vary in importance to patients, the frequency of events in the more and less important components, and the extent of variability in the relative risk reductions across components. DESIGN: Sys...

Subject

Medicine

End point

Randomized controlled trial

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