Machado‐Joseph disease gene product is a cytoplasmic protein widely expressed in brain

L. Paulson, Henry; S. Das, Sonal; B. Crino, Peter; K. Perez, Matthew; C. Patel, Sonal; B. Gotsdiner, Denise; H. Fischbeck, Kenneth; N. Pittman, Randall

doi:10.1002/ana.410410408

Public

Machado‐Joseph disease gene product is a cytoplasmic protein widely expressed in brain

Published in Annals of Neurology • Apr 1, 1997

Authors:

Henry L. Paulson

Sonal S. Das

Peter B. Crino

Abstract

Machado-Joseph disease (MJD) is one of at least six neurodegenerative diseases caused by expansion of a CAG repeat encoding a polyglutamine tract in the disease protein. To study the molecular mechanism of disease, we isolated both normal and expanded repeat MJD1 cDNAs, and generated antiserum again...

Subject

Polyglutamine tract

Machado–Joseph disease

Neurodegeneration

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