Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

Stéphenne, Xavier; Foretz, Marc; Taleux, Nellie; C. van der Zon, Gerard; Sokal, Étienne; Hue, Louis; Viollet, Benoı̂t; Guigas, Bruno

doi:10.1007/s00125-011-2311-5

Public

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

Published in Diabetologia • Sep 22, 2011

Authors:

Xavier Stéphenne

Marc Foretz

Nellie Taleux

Abstract

AIM/HYPOTHESIS: The glucose-lowering drug metformin has been shown to activate hepatic AMP-activated protein kinase (AMPK), a master kinase regulating cellular energy homeostasis. However, the underlying mechanisms remain controversial and have never been investigated in primary human hepatocytes. M...

Subject

Metformin

Protein kinase A

Human physiology

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